Activities

All the members of the Society are invited to attend the upcoming international conference at IMS BHU (Website):

“8th International Conference on “Cancer on fire: Inflammation and Immune System for Cancer Prevention and Treatment ” to be held in IMS, BHU
13-02-2020 to 16-02-2020

Research activities undertaken by various members of the society:

Dr. Dinesh and his team members (including Dr. Anupam, Dr. Sudipta Saha, Dr. Krishna Mohan Poluri and Prof. Narayan Prasad) are exploring the use of nanomedicines to develop infection resistant peritoneal dialysis (PD) fluid so that the patients suffering from End-stage-renal failure (ESRF) can be catered with a quality life (See the concept Note).

Dr. Gaurav Pandey and his team members (including Dr. Abhay Narayan Tiwari, Dr. Dinesh, and Dr. Sudipta Saha) are involved in evaluating the therapeutic efficacy of probiotics supplemented with turmeric in the treatment of various gastrointestinal diseases such as liver cirrhosis.

Dr. Abhay Narayan Tiwari and his team members (including Dr. Gaurav Pandey, Dr. Dinesh, and Dr. Vikas Agarwal) are extensively involved in evaluating the therapeutic efficacy and safety of Swarnaprashana as a curative and preventative medicine for a variety of human diseases such as liver cirrhosis.

Dr. V Karthick (Scientist, Sathyabama Institute of Science and Technology) and his team members (including Dr. Dinesh from CBMR, Lucknow) are involved in developing infection-resistant catheters for peritoneal dialysis using multi-walled carbon nanotubes.

Dr. Anupam (from CBMR, Lucknow) and his team members (including Dr. Dinesh, Dr. Krishna Mohan Poluri and Prof. Narayan Prasad) are involved in developing compatible Gadlinium based magnetic nanopartcle systems for various theranostic applications.

Dr. Krishna Mohan Poluri and his team members are extensively involved in studying the Immune regulatory proteins such as cytokines, Growth factors, chemokines and linear sulfated carbohydrate polymers such as glycosaminoglycans (GAGs). These molecules play a major role during leukocyte trafficking, in resolving inflammation and infections. Moreover, these classes of proteins and GAGs are now extensively applied to formulate resorbable polymeric matrices for tissue regeneration. We are assessing the potential role of several flavonoids and their glycosides for their anti-inflammatory and Immunomodulatary properties. Their binding interactions with natural proteins and GAGs are being studied in order them to be considered as nutraceuticals against immune disorders.

Dr. Subash Chandra Gupta and his Cancer Biology group is exclusively involved in evaluating the anti-cancer activities of natural compounds derived from plant sources such as Premna herbacea, Clerodendrum indicumTurmeric  (Curcuma longa and its other tropical varieties). Mainly, his research involves targeting inflammatory pathways in the tumor microenvironment for breast cancer therapy.

Dr. Sandip Chatterjee has keen interest to evaluate the biological activities of various natural compounds extracted from Annona muricata (in India popularly known shul-ram-fal and hanuman fal) owing to its medicinal properties. During his PhD, he has been involved in the total synthesis of (−)-muricatacin (See here) which is obtained from the seeds of Annona muricata and exhibits promising anti-cancer activity (See here).

Dr. Venkatesh Kumar R and his team members (including Dr. Sudipta Saha and others) are involved in isolation and structure elucidation of biologically active metabolites from plant, fungi, bacteria and insects sources. The identified novel natural compounds are further tested for their biological activities against various pathogenic strains and cancer types. Additionally, he is also working on interdisciplinary areas of Sericulture / Entomology and Natural Products to provide scientific validation for natural products and/or for biological-based organisms to serve as useful materials for the interests of human beings either in terms of nutraceuticals or preparing the novel drug formulations.

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Members

Founder Members of the Society:

[1] Prof. Ramakrishna V. Hosur (TIFR, Mumbai) Webpage

[2] Prof. C L Khetrapal (Founder Director, CBMR). Webpage

[3] Prof. MLB Bhatt (Vice Chancellor, King George’s Medical University, Lucknow): Webpage

[4] Prof. Raja Roy (Director, CBMR, Lucknow). Webpage

[5] Dr. Dinesh Kumar (Assistant Professor, CBMR, Lucknow): Webpage

[6] Dr. Krishna Mohan Poluri (Associate Professor, IIT Roorkee): Webpage

[7] Prof. Shubhini Saraf (Professor, Dept. of Pharmaceutical Sciences, BBAU, Lucknow): Webpage

[8] Dr. Gaurav Pandey (Assistant Professor, Dept. of Gastroenterology, SGPGIMS, Lucknow): Webpage

[9] Dr. Abhay Narayan Tiwari (Harsh Ayurvedic, Gomti Nagar, Lucknow-226010):Webpage

[10] Dr. Subhash Chandra Gupta (Assistant Professor, Institute of Science, Banaras Hindu University, India) Webpage

[11] Prof. Vikas Agarwal (Professor, Dept. of Clinical Immunology, SGPGIMS Lucknow): Webpage

[12] Dr. Sudipta Saha (Assistant Professor, Dept. of Pharmaceutical Sciences, BBAU, Lucknow): Webpage

[13] Dr. Venkatesh Kumar R (Assistant Professor, Dept. of Applied Animal Sciences, BBAU, Lucknow):Webpage

[14] Prof. Pritam Deb (Department of Physics, Tezpur University, Assam): Webpage

[15] Prof. Rajavashisth Tripathi (Institute of Medical Sciences, Banaras Hindu University):Webpage 

[16] Dr. Anupam Guleria (DST-Inspire Faculty, CBMR, Lucknow): Webpage

[17] Prof. Dinesh Raj Modi (HOD, Dept. of Biotechnology, BBAU, Lucknow): Webpage

[18] Dr. Gaurav Kaithwas (Associate Professor, Dept. of Pharmaceutical Sciences, BBAU, Lucknow): Webpage

[19] Dr. Vikas Kumar (Assistant Professor, SHUATS Allahabad): Webpage

[20] Prof. Palwinder Singh (Professor, Department of Chemistry, GNDU, Amritsar): Webpage

[21] Dr. Anirban Bhunia (Associate Professor, Dept. of Biophysics,Centenary Campus Bose Institute, Kolkata): Webpage

[22] Dr. Sunil Kumar (Associate Professor at Faculty of Biotechnology, Shri Ramswaroop Memorial University, Lucknow (UP) Webpage

[23] Dr. Mahesh Sharma (Associate Professor, University of Rajasthan, Jaipur). Currently heading Biosap company.  Webpage

[24] Dr. Ashutosh Shrivastava (Assistant Professor, Department of Molecular Biology, a unit of CFAR, KGMC, Lucknow): Webpage

[25] Dr. Khushboo Gulati (Post-Doc, IIT Roorkee): Webpage

[26] Dr. Atul Kumar Srivastava (Post-Doc, Department of Pathology, University of Chicago Chicago, IL-60637). Webpage

[27] Dr. V Karthick (Scientist, Sathyabama Institute of Science and Technology): Webpage

[28] Dr. Sandeep Singh (President ISET) Webpage

[29] Dr. Virendra Kumar (Associate Professor, Department of Nuclear Magnetic Resonance Imaging, All India Institute of Medical Sciences, New Delhi, India) @ResearchGate

[30] Dr. Naresh Chandra Bal (Associate Professor, School of Biotechnology, Kalinga Institute of Industrial Technology,Bhubaneswar-751024, Odisha). Webpage

[31] Dr. G. Sunil Babu (Dept. of Biotechnology, Babasaheb Bhimrao Ambedkar University (BBAU), Lucknow): Google Scholar Page

[32] Dr. Gyanendra Sharma (Natural and Green Chemistry Division, CSIR-CSMCRI, Bhavnagar, Gujrat, India): LinkedIN Profile

[33] Dr. Ranjan Khunt (Research scientist at Saurashtra University, Rajkot, Gujarat, India): LinkedIn

[34] Dr. Banappa S Unger (Scientist-D, Pharmacology Division, ICMR-NITM, Belagani, Karnataka) Email: banappau@icmr.gov.in. Webpage

[35] Dr. Ashish Gupta (Assistant Professor, CBMR, Lucknow working in the area of Clinical Metabolomics @ResearchGate

[36] Dr. Krishna Srivastava (HOD, Department of Chemistry, Shri Ramswaroop Memorial University (SRMU), DEVA ROAD, Lucknow) @ResearchGate

——-

Life Members:

[1] Dr. Vivek Mishra (Assistant Professor, Division of Life Sciences at Navrachana University, Vadodara): Webpage

[2] Dr. Rudra N Purusottam (Post Doc, NIH): Webpage

[3] Dr. Ashok Kumar Singh (Assistant Professor, Department of Pharmacy, Institute of Technology and Management, GIDA, Gorakhpur, India): Webpage

[4] Dr.Vaivav Kumar Shukla (Post-Doc, University College London, UK): Webpage

[5] Dr. Akhilesh Sharma (Post-Doc, Fukui Institute for Fundamental Chemistry, Kyoto University, Japan) Expertize: Computational Chemistry WebPage

[6] Dr. Rajan Singh (PhD from SGPGIMS, Lucknow, Currently Postdoctoral Fellow
School of Medicine, Dept of Physiology and Cell Biology, Center for Molecular Medicine
University of Nevada, Reno, NV 89557, USA. Email rajans@med.unr.edu @ResearchGate

[7] Dr. Kamal Dua (Lecturer, Pharmacy, University of Technology Sydney @ResearchGate): Webpage

[8] Dr. Rose Dawn Bharath (Neuroradiologist, National Institute of Mental Health and Neuro Sciences (NIMHANS), India): Google Scholar

[9] Dr. Ashok Rout (Post Doc, Department of NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany) Webpage

[10] Dr. Chirag Rathod (Currently working as Lecturer, Department of Chemistry, RK University, Rājkot, India) Webpage

[11] Dr Ashish Guleria (Assistant Professor, WIT Dehradun, Uttrakhand, India) Google Scholar Page

[12] Dr. Sandip Chatterjee (Post-Doctoral RA under DST-SERB Project, CBMR, Lucknow).

[13] Dr. Vivek Singh (MBBS, MD, KGMU, Lucknow).

[14] Dr. Alok Kumar Singh (Post-Doctoral RA, CBMR, Lucknow).

[15] Dr. Shailaja Rao (Professor, SDM College of Ayurveda and Hospital, Hassan, Karnataka) @Facebook

[16] Prasanna Narasimha Rao (Principal (School) at SDM College of Ayurveda and Hospital @Facebook

 

Note: For joining the Society, the researchers or scientists may write directly to the following TBRSI members:

(A) Dr. Dinesh Kumar (Currently serving as The President of the Society) Email ID: dineshcbmr@gmail.com

(B) Dr. Krishna Mohan Poluri (Currently serving as The Vice-President of the Society) Email ID: mohanpmk@gmail.com

Genesis

Traditional Herbal Medicines (THMs) have been used in the treatment of variety of diseases for thousands of years in India and other Asian Countries because of their natural origin and lesser side effects. However, the safety and efficacy data (in addition to dose and quality parameters) on most of these THMs are far from sufficient to meet the criteria needed to support their world-wide therapeutic use [1,2]. Also, the mechanistic understanding of most of such natural herbal medicines is still lacking [2].  It is assumed that THMs (and so the nutraceuticals) promotes self-healing through establishing and maintaining the homeostasis of organ systems in the body, and interactions with the environment [3,4]. Fundamentally, the biological activity of any THM is the combined effect of its various constituents that interact with various cellular components (i.e. DNA, RNA, and proteins) to exert synergistic effect.

Kumar Figure 1

Similar to THMs, the scientific evidences of therapeutic efficacy and safety for majority of nutraceutical products and natural medicines is also lacking. Nutraceutical is a hybrid term for ‘nutrition’ and ‘pharmaceutical’ and represents a plant or animal derived product which has its significant role in modifying and maintaining normal physiological function; this in turn helps ameliorating the diseased condition [4]. Recent years have witnessed tremendous growth in the market of nutraceutical products and natural herbal medicines owing to their ability to combat some of the major health problems of the century such as obesity, cardiovascular diseases, respiratory diseases, cancer, osteoporosis, arthritis, diabetes, hypercholesterolemia, etc. [4]. However, it is important to establish the scientific rationale to defend their world-wide therapeutic use in human healthcare managament. Thus, conscience efforts are required to well ensure the efficacy and safety of nutraceutical products, especially those marketed for health-care management of serious human diseases such as cancer. The aim of TBRSI is to promote translational research efforts, especially, in the area of Nutraceuticals and Natural Medicines through promoting collaborations among:

  • OMICS Researchers working in the area of natural products
  • Pre-clinical and Clinical researchers
  • Pharmaceutical and Toxicological Researchers
  • Healthcare Professionals
  • Industrial Professionals
  • Scientists and students from research institutes organizations and universities
  • Pharmaceutical companies, Investors and CEO’s

References:

[1] Web-source: https://nccih.nih.gov/health/ayurveda/introduction.htm

[2] Dinesh Kumar*, Atul Rawat, Durgesh Dubey, Umesh Kumar, Amit K Keshari, Sudipta Saha and Anupam Guleria*, “NMR Based Metabolomics: An Emerging Tool for Therapeutic Evaluation of Traditional Herbal Medicines”. SM-eBOOK: Nuclear Magnetic Resonance Spectroscopy (2016), June, 1-18. Download

[3] Web-source: https://nationaleczema.org/traditional-chinese-medicine-and-eczema/

[4] Charaka Samhita: https://en.wikipedia.org/wiki/Charaka_Samhita

[5] Das L, Bhaumik E, Raychaudhuri U, Chakraborty R. Role of nutraceuticals in human health. Journal of food science and technology. 2012 Apr 1;49(2):173-83. Online

 

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